UltimateNicheDomination

When NEED is there, rather than just desire, you've got a winning niche. Combine that with a laser targeted campaign that provides a solution to their problem and you'll never struggle to make money again.
The best place to start with finding a good desperate niche is to use minor keyword research to find what people want to fix. You don't need to use any high-priced tools… just searching in any browser will do, or you can use Google Suggest.
Whenever you search for something with Google, it will give you suggestions as you type for related keywords. This is one very easy way to find some potentially desperate niches.